Persistent decline over 3 years in physical function predicts 15-year mortality in ambulatory older menReport as inadecuate

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(2015)EUROPEAN GERIATRIC MEDICINE.6(suppl. 1).p.S8-S8 Mark abstract Objectives: Physical function measurements can predict important adverse outcomes in older persons, but little is known about the predictive value of longitudinal changes in these measurements. This study evaluated the effects of transient and persistent decline over three years from baseline in physical function on 12 year mortality. Methods: This community-based cohort study included ambulatory men aged ≥71, living in the community of Merelbeke (municipality of Ghent, Belgium). Participants’ physical function and decline from baseline were assessed annually over three years using the following measurements and cut-off points: Timed Up and Go (2 sec), Chair Rise (1 sec), Balance (1 point), Grip strength (6kg), General Health (Short Form-36 item; 15 points), Physical Function (Short Form-36 item; 20 points) and Activities of Daily Living (ADL; Rapid Disability Rating Scale-2 questions; 2 points). Decline was considered persistent or transient based on whether the decline was still present at the end of year three. Results: Of 162 older men with complete annual physical function assessments from 1997 until 2000, 107 (66%) died within the subsequent 12 years. Mortality risk increased with persistent decline in Timed Up and Go (HR=2.15, 95%CI=1.24–3.73), Grip strength (HR=3.39, 95% CI=1.45–7.93), Physical Function (HR=2.51, 95%CI=1.43–4.41), General Health (HR=3.07, 95%CI=1.69–5.60), and ADL score (HR=3.30, 95%CI=1.43–7.63), compared with no decline. Decline in the last year in Chair Rise time (HR=2.63, 95%CI=1.39–4.98) and Balance (HR=2.39, 95%CI=1.10–5.18) also predicted death.Conclusions: Persistent decline in physical function affects mortality risk in ambulatory older men.

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Author: Stefanie De Buyser, Mirko Petrovic , Youri Taes, Bruno Lapauw , Kaatje Toye , Jean Kaufman and STEFAN GOEMAERE



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