Vascular endothelial growth factor VEGF, BCL-2, and BAX expression in fibropapilloma tumor tissue and skin tissue of sea turtles.Reportar como inadecuado


 Vascular endothelial growth factor VEGF, BCL-2, and BAX expression in fibropapilloma tumor tissue and skin tissue of sea turtles.


Vascular endothelial growth factor VEGF, BCL-2, and BAX expression in fibropapilloma tumor tissue and skin tissue of sea turtles. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.



Type of Resource: text

Genre: Electronic Thesis or Dissertation

Issuance: multipart monograph

Date Issued: 2009

Publisher: Florida Atlantic University

Physical Form: electronic

Extent: x, 58 p. : ill. (some col.).

Language(s): English

Summary: In sea turtles, the study of the etiology and development of fibropapillomatosis is not fully understood. Sea turtle fibropapillomatosis is a disease characterized by the proliferation of skin fibropapillomas and occasional internal fibromas. In this study, sea turtle fibropapilloma tumor and healthy tissue samples were used to look at VEGF, BCL-2 and Bax expression. Cancer tumors have a well established pattern of protein expression that involves overexpression of vascular endothelial growth factor (VEGF), responsible for the growth of new blood vessels, and a high BCL-2 to Bax ratio that leads to uncontrolled cell proliferation. Real time PCR was used to analyze VEGF expression, and Western blot techniques were used to measure BCL-2 and Bax expression. The results indicated that expression of VEGF was not significantly higher in tumor vs. skin tissue. For the differential expression of BCL-2 and Bax, the results were not in agreement with the established levels found in cancer studies, showing no significant change in BCL-2 expression and significantly higher levels of Bax in tumor vs. healthy tissue.

Identifier: 369176266 (oclc), 209981 (digitool), FADT209981 (IID), fau:3006 (fedora)

Note(s): by Angela Bancalari-Schmidlapp.Thesis (M.S.)--Florida Atlantic University, 2009.Includes bibliography.Electronic reproduction. Boca Raton, Fla., 2009. Mode of access: World Wide Web.

Subject(s): Sea turtles -- PhysiologyCancer -- PathophysiologyVascular endothelial growth factors -- PathophysiologyCellular signal transduction

Persistent Link to This Record: http://purl.flvc.org/FAU/209981

Owner Institution: FAU



Autor: Bancalari-Schmidlapp, Angela.

Fuente: http://fau.digital.flvc.org/islandora/object/fau%3A3006



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