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 Uncovering the role of the rodent dorsal hippocampus in spatial and object memory retrieval.


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Type of Resource: text

Genre: Electronic Thesis or Dissertation

Date Issued: 2011

Publisher: Florida Atlantic University

Physical Form: electronic

Extent: ix, 114 p. : ill. (some col.)

Language(s): English

Summary: Male C7BL/6J mice were implanted with bilateral dorsal CA1 guide cannulae. After confirming that intrahippocampal microinfusion of muscimol impaired hippocampal function, demonstrated by impaired performance in the Morris water maze, the influence of intrahippocampal muscimol was tested in the Novel Object Recognition paradigm. During a test session 24 h after the last habituation/sample session, mice were presented with one familiar object and one novel object. Successful retention of object memory was inferred if mice spent more time exploring the novel object than the familiar object. Results demonstrate that muscimol infused into dorsal CA1 region prior to the test session eliminates novel object preference, indicating that the hippocampus is necessary for the retrieval of this non-spatial memory - a topic that has garnered much debate. Understanding the similarities between rodent and human hippocampal function could enable future animal studies to effectively answer questions about diseases and disorders affecting human learning and memory.

Identifier: 740815361 (oclc), 3172696 (digitool), FADT3172696 (IID), fau:3661 (fedora)

Note(s): by Lisa Rios.Thesis (M.A.)--Florida Atlantic University, 2011.Includes bibliography.Electronic reproduction. Boca Raton, Fla., 2011. Mode of access: World Wide Web.

Subject(s): Rodents as laboratory animalsMemory -- ResearchCellular signal transductionCognitive neuroscienceHippocampus (Brain)Space perception

Persistent Link to This Record: http://purl.flvc.org/FAU/3172696

Owner Institution: FAU



Autor: Rios, Lisa.

Fuente: http://fau.digital.flvc.org/islandora/object/fau%3A3661



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