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 Two New Cytotoxic Linderazulenes from a Deep-Sea Gorgonian of the Genus Paramuricea.


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Type of Resource: text

Genre: article

Issuance: single unit

Date Issued: 2005

Publisher: American Chemical Society and American Society of Pharmacognosy

Extent: 4 p.

Physical Description: pdf

Language(s): English

Identifier: 3164111 (digitool), FADT3164111 (IID), fau:5612 (fedora)

Note(s): The known compound linderazulene (1) and two new linderazulenes (2, 3) were isolated from a deep-sea gorgonian Paramuricea sp. The structures of 2 and 3 were determined through spectroscopic methods. Compounds 1-3 show moderate in vitro cytotoxicity against the P388 murine leukemia cell line with IC50’s of 18.8, 2.7, and 15.6 µg/mL, respectively. Compound 2 showed moderate activity against the PANC-1 pancreatic cell line with an IC50 of 18.7 µg/mL.This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. Toaccess the final edited and published work see http://dx.doi.org/10.1021/np040147u. Thisarticle may be cited as: Reddy, N. S., Reed, J. K., Longley, R. E., & Wright, A. E. (2005). TwoNew Cytotoxic Linderazulenes from a Deep-Sea Gorgonian of the Genus Paramuricea. Journal of Natural Products, 68(2), 248-250.Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1571.

Subject(s): Paramuricea placomusDeep-sea ecologyCnidariaAzuleneSpectrum analysis

Persistent Link to This Record: http://purl.flvc.org/FCLA/DT/3164111

Links: http://dx.doi.org/10.1021/np040147u

Restrictions on Access: ©2005 American Chemical Society and American Society of Pharmacognosy

Owner Institution: FAU



Autor: Reddy, N. Srinivasa, creator Reed, John K., creator Longley, Ross E., creator Wright, Amy E., creator

Fuente: http://fau.digital.flvc.org/islandora/object/fau%3A5612



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