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 Pathogenesis of idiopathic restrictive cardiomyopathy.

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Type of Resource: text

Genre: Electronic Thesis or Dissertation

Date Issued: 2011

Publisher: Florida Atlantic University

Physical Form: electronic

Extent: xii, 85 p. : ill. (some col.)

Language(s): English

Summary: Restrictive cardiomyopathy (RCM) is a heart muscle disease, characterized by diastolic dysfunction. The present dissertation is to understand the mechanisms underlyijng the initiation of diastolic dysfunction and the fast disease progression to early death in a RCM mouse model, the transgenic cTnI193His mouse

. These data showed that myocardial ischemia occurred after diastolic dysfunction and before systolic dysfunction which proceeded congestive heart failure. The results demonstrate that myocardial ischemia causing cardiomycete death is a link between the initial diastolic dysfunction and late-stage systolic dysfunction, and accelerates the disease progression to fatal heart failure in the early age.

Identifier: 856904736 (oclc), 3362045 (digitool), FADT3362045 (IID), fau:4159 (fedora)

Note(s): by Yuejin Li.Thesis (Ph.D.)--Florida Atlantic University, 2011.Includes bibliography.Mode of access: World Wide Web.System requirements: Adobe Reader.

Subject(s): Mice as laboratory animalsHeart conduction systemCardiovascular system -- Diseases -- Genetic aspects

Persistent Link to This Record:

Owner Institution: FAU

Autor: Li, Yuejin.



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