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 Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp.


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Type of Resource: text

Genre: article

Date Issued: 2011

Publisher: Wiley

Place of Publication: Weinheim, Germany

Physical Form: pdf

Extent: 6 p.

Language(s): English

Identifier: FA00007465 (IID)

Note(s): Leiodermatolide is a structurally unique macrolide isolated from the deep-water marine sponge Leiodermatium sp. which exhibits potent antiproliferative activity against a range of human cancer cell lines and drastic effects on spindle formation in mitotic cells. Its unprecedented polyketide skeleton and stereochemistry were established using a combination of experimental and computational NMR methods.Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 1825This manuscript is an author version with the final publication available athttp://onlinelibrary.wiley.com/ and may be cited as: Paterson, I., Dalby, S. M., Roberts, J. C., Naylor,G. J., Guzmán, E. A., Isbrucker, R., Pitts, T. P., Linley, P., Divlianska, D., Reed, J. K., & Wright, A. E.(2011). Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp.Angewandte Chemie International Edition, 50(14), 3219-3223. doi: 10.1002/anie.201007719

Subject(s): Antimitotic AgentsMacrolidesSpongesMolecular structureNuclear Magnetic Resonance, BiomolecularCell lines

Links: http://dx.doi.org/10.1002/anie.201007719

Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00007465

Owner Institution: FAU



Autor: Paterson, I. Dalby, S. M. Roberts, J. C. Naylor, G. J. Guzmán, E. A. Isbrucker, R. Pitts, T. P. Linley, P. Divlianska, D. Reed,

Fuente: http://fau.digital.flvc.org/islandora/object/fau%3A33065



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