Isocation and characterization of conotoxins from the venom of Conus Planorbis and Conus Ferrugineus.Reportar como inadecuado


 Isocation and characterization of conotoxins from the venom of Conus Planorbis and Conus Ferrugineus.


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Type of Resource: text

Genre: Electronic Thesis or Dissertation

Issuance: single unit

Date Created: Spring 2014

Date Issued: 2014

Publisher: Florida Atlantic University

Physical Form: Online Resource

Extent: 95 p.

Language(s): English

Summary: The venom of marine gastropods belonging to the genus Conus has yielded numerousstructurally and functionally diverse peptidic components. The increase variety ofbioactive peptides identified in cone snail venoms is the product of the variety ofmolecular adaptations taken by Conus species in evolving neuroactive molecules to suittheir diverse biological purposes. Toxins from cone snails are classified into two majorgroups. One group consists of disulfide-rich peptides commonly termed conotoxins; thesecond group comprises peptides with only one disulfide bond or none.In this work, we present the discovery and characterization from the marine snails C.planorbis and C. ferrugineus. Both species are commonly found in the Indo-Pacific region and are very similar and is not distinguishable by size and shape of the shell.Novel P and T-Supefamiles were found in both species along with small linear peptideswith have a high frequency of tyrosine residues. Each chapter contains a detailed look atthe discovery process for the isolation and characterization of C. planorbis and C.ferrugineus. At discussion part, we also compared the peptides isolated in this work withother peptides from the literature.

Identifier: FA00004146 (IID)

Note(s): Includes bibliography.Thesis (M.S.)--Florida Atlantic University, 2014.

Subject(s): ConusGastropoda -- VenomPeptides -- StructureVenum

Held by: Florida Atlantic University Digital Library

Sublocation: Boca Raton, Fla.

Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00004146

Restrictions on Access: All rights reserved by the source institution

Owner Institution: FAU



Autor: Pak, Adriana, author Mari, Frank Dr., Thesis advisor Charles E. Schmidt College of Science, Degree grantor

Fuente: http://fau.digital.flvc.org/islandora/object/fau%3A13485



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