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 Caloric restriction in Drosophila melanogaster.

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Type of Resource: text

Genre: thesis

Issuance: multipart monograph

Date Issued: 2012

Physical Form: electronic

Physical Form: electronic resource

Extent: iv, 21 p. : ill. (some col.)

Language(s): English

Summary: Caloric restriction (CR), the reduction of nutrient intake short of malnutrition, extends the lifespan of various organisms and can improve measures of human health. Whether mechanisms of lifespan extension are conserved between humans and model organisms is unknown. In mammals, implementing CR is easily achieved by providing a restricted group with a fraction of the food consumed by an ad libitum fed group, which has unlimited food access. Due to the difficulty in directly controlling Drosophila food intake, caloric restriction, performed similarly to the mammalian paradigm, has never been tested in flies. Here, we demonstrate a system that allows measurement of food intake throughout life. This system will be used to measure fly lifespan under caloric restriction analogous to current mammalian studies. Our work will help tease apart the differences between the various caloric and dietary restriction paradigms in Drosophila, strengthening our understanding of how fly models relate to mammalian systems.

Identifier: 818755191 (oclc), 3359316 (digitool), FADT3359316 (IID), fau:1444 (fedora)

Note(s): by Sany Hoxha.Thesis (B.A.)--Florida Atlantic University, 2012.Includes bibliography.Electronic reproduction. Boca Raton, Fla., 2012. Mode of access: World Wide Web.

Subject(s): Aging -- Physiological aspectsNutrition disorders in old ageOxidative stress -- Pathophysiology

Held by: FBoU FAUER

Persistent Link to This Record:

Owner Institution: FAU

Autor: Hoxha, Sany.



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