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Molecular Cancer

, 16:130

First Online: 24 July 2017Received: 14 March 2017Accepted: 11 July 2017


Long-noncoding RNAs lncRNAs are a group of transcripts that are longer than 200 nucleotides and do not code for proteins. However, this class of RNAs plays pivotal regulatory roles. The mechanism of their action is highly complex. Mounting evidence shows that lncRNAs can regulate cancer onset and progression in a variety of ways. They can not only regulate cancer cell proliferation, differentiation, invasion and metastasis, but can also regulate glucose metabolism in cancer cells through different ways, such as by directly regulating the glycolytic enzymes and glucose transporters GLUTs, or indirectly modulating the signaling pathways. In this review, we summarized the role of lncRNAs in regulating glucose metabolism in cancer, which will help understand better the pathogenesis of malignant tumors. The understanding of the role of lncRNAs in glucose metabolism may help provide new therapeutic targets and novel diagnostic and prognosis markers for human cancer.

KeywordsLncRNAs Glucose metabolism Warburg effect Signaling pathway Targeted therapy AbbreviationsACCAcetyl coA carboxylase

ACLATP-citrate lysase

CREB-CRTCCyclic AMP-responsive element -bingding protein-CREB-regulated transcription coactivator

CRNDEColorectalneoplasia differentially expressed

EGFREpidermal growth factor receptor

EMTEpithelial-mesenchymal transition


FBPFructose bisphosphate

FDG-PETFluorodeo-xygucose positron emission tomography


GLUTGlucose transporter

HIFHypoxia-induced factor


HOTAIRHox transcript antisense RNA

LDHLactic dehydrogenase

LINK-ALong intergenic non-coding RNA for kinase activation

LKB1The liver kinase B1

lncRNA MALAT1Metastasis-associated lung adenocarcinoma transcript 1

lncRNA NBR2Neighbour of BRCA1 gene 2

LncRNALong non-coding RNA

MEG3Maternally expressed gene 3

mTORMamalian target of rapamycin

OXPHOSOxidative phosphorylation

PDHPyruvate dehydrogenase

PDK1Pyruvate dehydrogenase 1

PEPCKPhosphoenolpyruvate carboxykinase

PFKPhosphoric acid fructose kinase

PFK16-phosphofructokinase 1

PGMPhosphglycerate mutase

PI3Kthe phosphoinositide 3-kinase

PKPyruvate kinase

PKM2Pyruvate kinase 2

PMLPromyelocytic leukemia


ROSReactive oxygen species

STATSignal transducer and activator of transcription

TIGARTP53-induced glycolysis andapoptosis regulator

VHLVon Hippel-Lindau

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Autor: Chunmei Fan - Yanyan Tang - Jinpeng Wang - Fang Xiong - Can Guo - Yumin Wang - Shanshan Zhang - Zhaojian Gong - Fang Wei


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