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Human Genomics

, 11:17

First Online: 24 July 2017Received: 22 May 2017Accepted: 18 July 2017

Abstract

BackgroundLong non-coding RNAs lncRNAs are a sub-class within non-coding RNA repertoire that have emerged as crucial regulators of the gene expression in various pathophysiological conditions. lncRNAs display remarkable versatility and wield their functions through interactions with RNA, DNA, or proteins. Accumulating body of evidence based on multitude studies has highlighted the role of lncRNAs in many autoimmune and inflammatory diseases, including type 1 diabetes T1D.

Main body of abstractThis review highlights emerging roles of lncRNAs in immune and islet β cell function as well as some of the challenges and opportunities in understanding the pathogenesis of T1D and its complications.

ConclusionWe accentuate that the lncRNAs within T1D-loci regions in consort with regulatory variants and enhancer clusters orchestrate the chromatin remodeling in β cells and thereby act as cis-trans-regulatory determinants of islet cell transcriptional programs.

KeywordsLong non-coding RNAs Type 1 diabetes Enhancers Regulatory elements 3D genome architecture AbbreviationseQTLExpression quantitative trait loci

GWASGenome-wide association studies

LDLinkage disequilibrium

lncRNALong non-coding RNA

SNPSingle-nucleotide polymorphism

TFTranscription factor

TFBSTranscription factor binding site

T1DType 1 diabetes

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Autor: Aashiq H. Mirza - Simranjeet Kaur - Flemming Pociot

Fuente: https://link.springer.com/



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