Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional studyReportar como inadecuado




Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Environmental Health

, 16:80

Children’s Environmental Health

Abstract

BackgroundAnimal studies suggest that bisphenol A BPA may perturb pubertal development in females. However, evidence from human studies is limited.

MethodsThis was a cross-sectional study to investigate the association between BPA exposure and pubertal development in school-aged girls. A total of 655 girls aged 9–18 years were selected from three schools in Shanghai, from May to June 2011. We collected one single spot urine sample from each girl. Urine BPA concentrations were measured by modified high-performance liquid chromatography and categorized according to LOD and the median of those above LOD. Pubertal development status was assessed by using Tanner staging, and age at menarche was collected as a milestone for mid-puberty. Modified Poisson regression was used to estimate adjusted prevalence ratios PRs and 95% confidence intervals CIs.

ResultsAfter adjustment for potential confounders, girls with detected BPA were more likely to have delayed menarche, a mid-puberty event, compared with girls with undetectable BPA; the prevalence ratios PR were 0.73 0.56, 0.95 for those with moderate BPALOD-median and 0.72 0.52, 0.99 for those with high BPA>median, respectively. Girls aged 9–12 years with detected BPA were more likely to have reached pubic hair stage 2, the indicator of pubarche; while among girls aged >15 years, those with detected BPA were less likely to have reached pubic hair stage 5, the late stage of pubic hair development.

ConclusionsBPA exposure was associated with alterations in the timing of pubertal development. Results in the present study should be interpreted with caution because of its cross-sectional nature and the limited sample size in each age group.

KeywordsBisphenol A Endocrine disruptor Girl Puberty Tanner stage AbbreviationsBMIBody mass index

BPABisphenol A

CIsConfidence intervals

LODLIMIT of detection

PRsPrevalence ratios

Download fulltext PDF



Autor: Maohua Miao - Ziliang Wang - Xiaoqin Liu - Hong Liang - Zhijun Zhou - Hui Tan - Wei Yuan - De-Kun Li

Fuente: https://link.springer.com/







Documentos relacionados