Six years genotype distribution of Human Papillomavirus in Calabria Region, Southern Italy: a retrospective studyReport as inadecuate

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Infectious Agents and Cancer

, 12:43

Clinical oncology


BackgroundAlthough analysis of the Human papillomavirus HPV genotype spread in a particular area has a crucial impact on public health and prevention programmes, there is a lack of epidemiological data regarding HPV in the Calabria region of Italy. We therefore update information on HPV age-genotype distribution by retrospectively analysing a cohort of women, with and without cervical lesions, living in Calabria, who underwent HPV DNA testing; moreover, we also evaluated HPV age-genotype distribution in a subset of patients with cervical lesions.

MethodsCervical scrape specimens obtained from 9590 women age range 20–75 years from January 2010 to December 2015 were tested for HPV DNA. Viral types were genotyped by Linear Array HPV Genotyping® test Roche, USA at the Clinical Microbiology Operative Unit of six hospitals located in four provinces of the Calabria region.

Cervical scrape specimens were also used to perform Pap smears for cytological analysis in a subset of 405 women; cytological classification of the samples was performed according to the Bethesda classification system.

ResultsA total of 2974 women 31% C.I. 95% 30.09–31.94 were found to be HPV DNA positive for at least one 57.3% or several 42.7% HPV genotypes. Of single genotype HPV infections, 46.5% and 36.4 % were classed as high-risk HR, Group 1 and low-risk LR, Group 3 respectively, while 16.9% were classed as probably-possibly carcinogenic and 0.2% undetermined risk. Stratified by age, total HPV distribution, showed the highest prevalence within the range 30–39 years 37.2%, while single genotype infection distribution displayed a peak in women from the age range 20–29 years 37.5%. The most common high-risk HPV type was HPV 16 19.1%, followed by HPV 31 9.1%.

ConclusionsWe provide epidemiological data on HPV age-genotype distribution in women living in the Calabria region with or without cytological abnormalities, further to the enhancement of HPV screening-prevention programmes for the local population.

KeywordsHPV Epidemiology Genotypes distribution Calabria Region AbbreviationsHPVHuman papillomavirus

HRHigh risk

IARCInternational agency for research on cancer

LALinear array

LRLow risk

PCRPolymerase chain reaction

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Author: Luisa Galati - Cinzia Peronace - Maria Teresa Fiorillo - Rosanna Masciari - Cristina Giraldi - Salvatore Nisticò - Pasqual


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