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BMC Neurology

, 17:142

Demyelinating diseases

Abstract

BackgroundPost-traumatic Guillain-Barré syndrome GBS is a rarely described potentially life-threatening cause of weakness. We sought to elucidate the clinical features and electrophysiological patterns of post-traumatic GBS as an aid to diagnosis.

MethodsWe retrospectively studied six patients diagnosed with post-traumatic GBS between 2014 and 2016 at Tianjin Medical University General Hospital, China. Clinical features, serum analysis, lumbar puncture results, electrophysiological examinations, and prognosis were assessed.

ResultsAll six patients had different degrees of muscular atrophy at nadir and in two, respiratory muscles were involved. Five also had damaged cranial nerves and four of these had serum antibodies against gangliosides. The most common electrophysiological findings were relatively normal distal latency, prominent reduction of compound muscle action potential amplitude, and absence of F-waves, which are consistent with an axonal form of GBS.

ConclusionsIt is often overlooked that GBS can be triggered by non-infectious factors such as trauma and its short-term prognosis is poor. Therefore, it is important to analyze the clinical and electrophysiological features of GBS after trauma. Here we have shown that electrophysiological evaluations are helpful for diagnosing post-traumatic GBS. Early diagnosis may support appropriate treatment to help prevent morbidity and improve prognosis.

KeywordsPost-traumatic GBS GBS Trauma Electrophysiology Axonal damage AbbreviationsAIDPAcute inflammatory demyelinating polyneuropathy

AMANAcute motor axonal neuropathy

AMSANAcute motor sensory axonal neuropathy

CMAPCompound muscle action potential

CSFCerebrospinal fluid

DLDistal latency

ELISAEnzyme-linked immunosorbent assay

GBSGuillain-Barré syndrome

HFGSHughes Functional Grading Scale

MCVMotor nerve conduction velocity

MRCMedical Research Council

NCSNerve conduction study

SCVSensory nerve conduction velocity

SNAPSensory nerve action potential

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Autor: Xiaowen Li - Jinting Xiao - Yanan Ding - Jing Xu - Chuanxia Li - Yating He - Hui Zhai - Bingdi Xie - Junwei Hao

Fuente: https://link.springer.com/







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