Impact of hypertension with or without diabetes on left ventricular remodeling in rural Chinese population: a cross-sectional studyReportar como inadecuado

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BMC Cardiovascular Disorders

, 17:206

First Online: 27 July 2017Received: 03 June 2017Accepted: 21 July 2017


BackgroundThe aim of this study was to assess the impact of hypertension with or without diabetes on left ventricular LV remodeling in rural Chinese population.

MethodsA total of 10,270 participants were classified into control group, hypertension without diabetes HT group, and hypertension with diabetes HT + DM group. We compared clinical characteristics and echocardiographic parameters, and used multivariable logistic regression analysis to assess the associations of interest.

ResultsHT + DM group had higher interventricular septal thickness IVSd, posterior wall thickness PWTd, left ventricular mass LVM, LVM index LVMI, relative wall thickness RWT, left atrial diameter LAD, A wave and lower E wave than HT group all P < 0.05. The prevalence rates of left ventricular hypertrophy LVH and abnormal geometry were statistically different among three groups P < 0.001 and eccentric hypertrophy was the highest proportion of geometry abnormality. Logistic regression analysis suggested that subjects in HT and HT + DM groups had odds ratio OR values of 2.81, 4.41, 2.24 and 3.94, 7.20, 2.38 for LVH, concentric hypertrophy and eccentric hypertrophy in the total population, respectively, compared to control group. When compared with HT group, those in HT + DM group had approximately 1.40-, 1.61- and 1.38-, 1.71-fold increased risk for LVH and concentric hypertrophy in the total and female population separately, but no association of HT + DM with LVH and abnormal geometrical patterns was found in men.

ConclusionsThis study demonstrated that, to varying degrees, hypertension was associated with LV remodeling in rural Chinese population, and this risk association was obviously increased for LVH and concentric hypertrophy when accompanied by diabetes, especially for women.

KeywordsHypertension Diabetes Left ventricular remodeling Left ventricular geometry AbbreviationsAAtrial peak flow

AODAortic annular diameter

BMIBody mass index

BSABody surface area

DBPDiastolic blood pressure

EEarly transmitral diastolic peak flow

EFEjection fraction

FPGFasting plasma glucose

FSFractional shortening

HDL-CHigh-density lipoprotein cholesterol

IVSdInterventricular septal thickness

LADLeft atrial diameter

LDL-CLow-density lipoprotein cholesterol

LVLeft ventricular

LVEDVLV end-diastolic volume

LVESVLV end-systolic volume

LVHLeft ventricular hypertrophy

LVIDdLV end-diastolic internal dimension

LVIDsLV end-systolic internal dimension

LVMLeft ventricular mass

LVMILeft ventricular mass index

PCPlasma creatine

PWTdPosterior wall thickness

RWTRelative wall thickness

SBPSystolic blood pressure

TCTotal cholesterol


WCWaist circumference

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Autor: Tan Li - Shuang Chen - Xiaofan Guo - Jun Yang - Yingxian Sun


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