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International Journal of Bipolar Disorders

, 5:27

First Online: 01 August 2017Received: 09 December 2016Accepted: 18 April 2017


BackgroundConcerns about potential adverse effects of long-term exposure to lithium as a mood-stabilizing treatment notably include altered renal function. However, the incidence of severe renal dysfunction; rate of decline over time; effects of lithium dose, serum concentration, and duration of treatment; relative effects of lithium exposure vs. aging; and contributions of sex and other factors all remain unclear.

MethodsAccordingly, we acquired data from 12 collaborating international sites and 312 bipolar disorder patients 6142 person-years, 2669 assays treated with lithium carbonate for 8–48 mean 18 years and aged 20–89 mean 56 years. We evaluated changes of estimated glomerular filtration rate eGFR as well as serum creatinine, urea–nitrogen, and glucose concentrations, white blood cell count, and body-mass index, and tested associations of eGFR with selected factors, using standard bivariate contrasts and regression modeling.

ResultsOverall, 29.5% of subjects experienced at least one low value of eGFR <60 mL-min-1.73 m, most after ≥15 years of treatment and age > 55; risk of ≥2 low values was 18.1%; none experienced end-stage renal failure. eGFR declined by 0.71%-year of age and 0.92%-year of treatment, both by 19% more among women than men. Mean serum creatinine increased from 0.87 to 1.17 mg-dL, BUN from 23.7 to 33.1 mg-dL, glucose from 88 to 122 mg-dL, and BMI from 25.9 to 26.6 kg-m. By multivariate regression, risk factors for declining eGFR ranked: longer lithium treatment, lower lithium dose, higher serum lithium concentration, older age, and medical comorbidity. Later low eGFR was also predicted by lower initial eGFR, and starting lithium at age ≥ 40 years.

LimitationsControl data for age-matched subjects not exposed to lithium were lacking.

ConclusionsLong-term lithium treatment was associated with gradual decline of renal functioning eGFR by about 30% more than that was associated with aging alone. Risk of subnormal eGFR was from 18.1% ≥2 low values to 29.5% ≥1 low value, requiring about 30 years of exposure. Additional risk factors for low eGFR were higher serum lithium level, longer lithium treatment, lower initial eGFR, and medical comorbidity, as well as older age.

KeywordsBlood urea nitrogen Body-mass index Creatinine eGFR Glomerular filtration rate Glucose Lithium Staging of renal function White blood cell count  Download fulltext PDF

Autor: Leonardo Tondo - Maria Abramowicz - Martin Alda - Michael Bauer - Alberto Bocchetta - Lorenza Bolzani - Cynthia V. Calkin

Fuente: https://link.springer.com/

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