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Respiratory Research

, 18:149

First Online: 03 August 2017Received: 01 May 2017Accepted: 26 July 2017

AbstractOmics approaches are high-throughput unbiased technologies that provide snapshots of various aspects of biological systems and include: 1 genomics, the measure of DNA variation; 2 transcriptomics, the measure of RNA expression; 3 epigenomics, the measure of DNA alterations not involving sequence variation that influence RNA expression; 4 proteomics, the measure of protein expression or its chemical modifications; and 5 metabolomics, the measure of metabolite levels. Our understanding of pulmonary diseases has increased as a result of applying these omics approaches to characterize patients, uncover mechanisms underlying drug responsiveness, and identify effects of environmental exposures and interventions. As more tissue- and cell-specific omics data is analyzed and integrated for diverse patients under various conditions, there will be increased identification of key mechanisms that underlie pulmonary biological processes, disease endotypes, and novel therapeutics that are efficacious in select individuals. We provide a synopsis of how omics approaches have advanced our understanding of asthma, chronic obstructive pulmonary disease COPD, acute respiratory distress syndrome ARDS, idiopathic pulmonary fibrosis IPF, and pulmonary arterial hypertension PAH, and we highlight ongoing work that will facilitate pulmonary disease precision medicine.

KeywordsPulmonary diseases Genomics Transcriptomics Epigenomics Proteomics Metabolomics AbbreviationsARDSAcute respiratory distress syndrome

ChIP-SeqChromatin Immunoprecipitation Sequencing

COPDChronic obstructive pulmonary disease

eQTLExpression quantitative trait loci

EWASEpigenome-wide association studies

GEOGene Expression Omnibus

GWASGenome-wide association study

IPFIdiopathic pulmonary fibrosis

LCLiquid chromatography

MSMass spectrometry

NGSNext-generation sequencing

NHLBINational Heart, Lung, and Blood Institute

PAHPulmonary arterial hypertension

PBMCPeripheral blood mononuclear cell

pQTLProtein quantitative trait loci

PTMPost-translational modification

RNA-SeqRNA sequencing

scRNA-SeqSingle-cell RNA-Seq

SNPsingle nucleotide polymorphisms

SRASequence Read Archive

WESWhole-exome sequencing

WGSWhole-genome sequencing

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Autor: Mengyuan Kan - Maya Shumyatcher - Blanca E. Himes

Fuente: https://link.springer.com/







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