Antimicrobial activity of thiophene derivatives derived from ethyl E-5-3-dimethylaminoacryloyl-4-methyl-2-phenylaminothiophene-3-carboxylateReportar como inadecuado




Antimicrobial activity of thiophene derivatives derived from ethyl E-5-3-dimethylaminoacryloyl-4-methyl-2-phenylaminothiophene-3-carboxylate - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Chemistry Central Journal

, 11:75

Organic and Medicinal Chemistry

Abstract

BackgroundThe thiophene nucleus has been recognized as an important entity in the synthesis of heterocyclic compounds with promising pharmacological characteristics.

ResultsA number of new heterocyclic compounds incorporating thiophene species have been prepared from the titled enaminone via the reaction with different nucleophiles and electrophiles. The structure elucidation of the designed compounds was derived from their spectral information. The results of antimicrobial activity of the prepared compounds revealed that derivatives 7b and 8 exhibited activity comparable to the standard drugs ampicillin and gentamicin for all tested bacteria species. Additionally, compound 3 displayed potent activity against Aspergillus fumigates, whereas compounds 5 , 6 , and 7a showed good activity against Syncephalastrum racemosum.

ConclusionsWe have synthesized a number of new thiophene-containing compounds. The results of antimicrobial activity of the prepared compounds revealed that changing the substituents at position-2 of thiophene ring significantly affect their biological activity. The pyridine side chain derivatives in compounds 7a , 7b and 8 showed excellent antimicrobial activity.

KeywordsEnaminones Heteroamines Antimicrobial activity Heterocycles  Download fulltext PDF



Autor: Yahia Nasser Mabkhot - Nahed Ahmed Kaal - Seham Alterary - Salem S. Al-Showiman - Thoraya A. Farghaly - Mohammad S. Mub

Fuente: https://link.springer.com/







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