Long term safety and tolerability of Tafluprost 0.0015% vs Timolol 0.1% preservative-free in ocular hypertensive and in primary open-angle glaucoma patients: a cross sectional studyReportar como inadecuado




Long term safety and tolerability of Tafluprost 0.0015% vs Timolol 0.1% preservative-free in ocular hypertensive and in primary open-angle glaucoma patients: a cross sectional study - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Ophthalmology

, 17:136

Glaucoma`

Abstract

BackgroundThe effects of preservatives of antiglaucoma medications on corneal surface and tear function have been widely shown in literature; it’s not the same as regards the active compounds themselves. The purpose of our study was to compare Ocular Surface Disease OSD signs and symptoms of Tafluprost 0.0015% versus preservative free PF Timolol 0.1% eyedrops in ocular hypertensive OH and in primary open-angle glaucoma POAG patients.

MethodsA cross-sectional study included patients in monotherapy for at least 36 months with Tafluprost 0.0015% 27 or PF Timolol 0.1% 24 and 20 healthy age and sex-matched volunteers. All subjects underwent clinical tests Schirmer I and break-up time, in vivo confocal microscopy IVCM and were surveyed using Ocular Surface Disease Index OSDI and Glaucoma Symptoms Scale GSS questionnaires. The groups were compared with ANOVA, Kruskal-Wallis test, t-test, Mann-Whitney test and Bonferroni’s adjustment of p-values.

ResultsNo significant differences were found in questionnaires scores, clinical tests, IVCM variables between therapy groups. Tafluprost 0.0015% group showed significantly higher OSDI score, basal epithelial cells density, stromal reflectivity, sub-basal nerves tortuosity p = 0.0000, 0.037, 0.006, 0.0000 and less GSS score, number of sub-basal nerves p = 0.0000, 0.037 than controls but similar clinical tests results p > 0.05. PF Timolol group had significantly higher OSDI score, basal epithelial cells density, stromal reflectivity and sub-basal nerve tortuosity p = 0.000, 0.014, 0.008, 0.002, less GSS score, BUT and number of sub-basal nerves p = 0.0000, 0.026, 0.003 than controls.

ConclusionsCompared to PF Timolol 0.1%, Tafluprost 0.0015% showed similar safety with regards to tear function and corneal status and a similar tolerability profile. Both therapy groups show some alterations in corneal microstructure but no side effects on tear function except for an increased tear instability in PF Timolol 0.1% group. Ophtalmologists should be aware that even PF formulations may lead to a mild ocular surface impairment.

KeywordsPrimary open angle glaucoma Ocular surface Timolol preservative free Tafluprost In vivo confocal microscopy AbbreviationsGSSGlaucoma symptoms scale

IOPIntraocular pressure

IVCMIn vivo corneal confocal microscopy

MMPsMetalloproteinases

OHOcular hypertensive

OSDOcular surface diease

OSDOcular surface disease

OSDIOcular surface disease index

PFPreservative free

PGAProstaglandins analogs

POAGPrimary open angle glaucoma

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Autor: Teresa Rolle - Roberta Spinetta - Raffaele Nuzzi

Fuente: https://link.springer.com/







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