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Journal of Thrombosis and Thrombolysis

, Volume 42, Issue 3, pp 352–359

First Online: 22 June 2016

Abstract

Topical hemostatic agents are used intra-operatively to prevent uncontrolled bleeding. Gelfoam Powder contains a hemostatic agent prepared from purified pork skin gelatin, the efficacy of which is increased when combined with thrombin. However, the effect of increasing concentrations of thrombin on resultant hemostasis is not known. This study sought to evaluate the ability of various concentrations of thrombin in combination with Gelfoam Powder to control bleeding using a swine liver lesion model. Ten pigs underwent a midline laparotomy. Circular lesions were created in the left medial, right medial, and left lateral lobes; six lesions per lobe. Gelfoam Powder was hydrated with Thrombin–JMI diluted to 250, 375, and 770 IU-mL. Each concentration was applied to two lesion sites per lobe. Bleeding scores were measured at 3, 6, 9, and 12 min using a 6-point system; comparison of bleeding scores was performed using ANOVA with the post hoc Tukey test. The bleeding scores with thrombin concentrations at 770 IU-mL were significantly lower than at 250 and 375 IU-mL at all four time points. The percentage of biopsies with a clinically acceptable bleeding score rose from 37.9, 46.6, and 71.2 % at 3 min to 55.2, 69.0, and 88.1 % at 12 min in the 250, 375, and 770 IU-mL thrombin groups, respectively. The study showed that the hemostatic response to thrombin was dose-related: using higher concentrations of thrombin with Gelfoam Powder yielded improved hemostasis, as determined by lower bleeding scores.

KeywordsGelfoam Gelatin powder Thrombin Hemostasis Bleeding Swine  Download fulltext PDF



Autor: Dennis C. Morse - Elif Silva - Jolee Bartrom - Kelli Young - Eric J. Bass - David Potter - Trevor Bieber

Fuente: https://link.springer.com/



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