Preparation and characterization of nanosized Ag-SLN composite and its viability for improved occlusionReport as inadecuate

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Applied Nanoscience

, Volume 6, Issue 7, pp 1065–1072

First Online: 15 February 2016Received: 05 December 2015Accepted: 25 January 2016


Nanocomposites consisting of silver and solid lipid nanoparticles SLN elicit interest for their synergistic effect based enhanced properties in skin hydration. The nanocomposite preparation aims at combining the antimicrobial activity of silver with skin hydration performance of SLN. The nanocomposites designated Ag-SAN silver-stearic acid nanoparticles, Ag-PAN silver-palmitic acid nanoparticles were prepared by incorporating silver nanoparticles into the dispersion of SLN and sonicating for 10 min followed by heating for 1 h at 50 °C in a thermostat. The occlusive property of the two nanocomposites was evaluated in comparison with the pure SLN by adopting de Vringer-de Ronde in vitro occlusion test. The incorporation of silver nanoparticles has improved occlusion factor by 10 % in the case of both composites at SLN concentration of 0.14 mmol. Characterization studies include XRD, DSC, HRSEM, DLS and zeta potential measurement. High resolution scanning electron microscopy HRSEM images divulge that the nanoparticles of composite Ag-SAN shows halo effect where the hydrophobic stearic acid is oriented at the core and is surrounded by silver nanoparticles while Ag-PAN shows cashew shaped SLN dispersed in silver nanoparticles matrix.

KeywordsSilver nanoparticles SLN Nanocomposite Skin hydration Zetapotential HRSEM  Download fulltext PDF

Author: G. Cynthia Jemima Swarnavalli - S. Dinakaran - S. Divya


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