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The European Physical Journal Special Topics

, Volume 225, Issue 8–9, pp 1673–1682

Modern Simulation Approaches in Soft Matter Science: From Fundamental Understanding to Industrial Applications


Multivalent particles competing for binding on the same surface can exhibit switch-like behaviour, depending on the concentration of receptors on the surface. When the receptor concentration is low, energy dominates the free energy of binding, and particles having a small number of strongly-binding ligands preferentially bind to the surface. At higher receptor concentrations, multivalent effects become significant, and entropy dominates the binding free energy; particles having many weakly-binding ligands preferentially bind to the surface. Between these two regimes there is a -switch-point-, at which the surface binds the two species of particles equally strongly. We demonstrate that a simple theory can account for this switch-like behaviour and present numerical calculations that support the theoretical predictions. We argue that binding selectivity based on receptor density, rather than identity, may have practical applications.

Electronic supplementary materialSupplementary Online Material10.1140-epjst-e2016-60119-6

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Autor: N.B. Tito - D. Frenkel

Fuente: https://link.springer.com/

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