Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispaReportar como inadecuado

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Natural Products and Bioprospecting

, Volume 6, Issue 5, pp 247–255

First Online: 17 October 2016Received: 30 August 2016Accepted: 28 September 2016

AbstractFour new clerodane diterpenoids, tinosporols A–C 2 –4 and tinosporoside A 5 , together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpenoid borapetoside E 1 , the major component of the plant, was firstly established with the aid of molecular model. Compound 1 significantly reduced serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db-db type 2 diabetic mice.


AbstractOpen image in new windowKeywordsAnti-hyperglycemia Yuan Gao and Yan-Fen Niu contributed equally to this article.

Electronic supplementary materialThe online version of this article doi:10.1007-s13659-016-0109-3 contains supplementary material, which is available to authorized users.

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Autor: Yuan Gao - Yan-Fen Niu - Fei Wang - Ping Hai - Fang Wang - Yin-Dong Fang - Wen-Yong Xiong - Ji-Kai Liu


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