Effect of self-reported walking difficulty on bone mass and bone resorption marker in Japanese people aged 40 years and overReportar como inadecuado




Effect of self-reported walking difficulty on bone mass and bone resorption marker in Japanese people aged 40 years and over - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Physiological Anthropology

, 35:25

First Online: 11 October 2016Received: 03 April 2016Accepted: 30 September 2016

Abstract

BackgroundThis study aimed to examine the association of walking difficulty with bone mass or bone turnover among community-dwelling Japanese people aged 40 years and older.

MethodsWe studied 1097 community-dwelling Japanese people aged 40 years and older 379 men and 718 women who were invited to participate in periodic health examinations in 2006–2009. Walking difficulty was defined as having difficulty walking 100 m on a level surface self-administered questionnaire. Calcaneal stiffness index bone mass was measured by quantitative ultrasound. Spot urine samples were collected, and urinary N-terminal cross-linking telopeptide of type I collagen NTx was measured. Values were corrected for creatinine Cre concentration.

ResultsThe prevalence of walking difficulty was significantly higher in women than in men 7.4 vs. 3.4 %, p = 0.011 and significantly increased with age in men p for trend = 0.02 and women p for trend <0.001. In univariate analysis, men and women with walking difficulty were older p < 0.001 and had a lower stiffness index p < 0.001, compared with those without walking difficulty. Among women, individuals with walking difficulty had significantly higher urinary NTx-Cre than those without walking difficulty p < 0.001; however, this was not so among men p = 0.39. Multiple regression analysis adjusted for age, weight, and menopausal status showed a significant association between walking difficulty and lower stiffness index in men p = 0.004 and women p = 0.005. In women, walking difficulty was significantly associated with higher NTx-Cre p = 0.001, but not in men p = 0.35.

ConclusionsWalking difficulty may contribute to low bone mass in both sexes but might cause high bone turnover in women only.

KeywordsWalking difficulty Bone mass Calcaneal stiffness index Bone turnover AbbreviationsBCEBone collagen equivalents

BMIBody mass index

CreCreatinine

NTxUrinary cross-linked N-telopeptide of type I collagen

QUSQuantitative ultrasound

SDStandard deviation

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Autor: Yasuyo Abe - Takayuki Nishimura - Kazuhiko Arima - Mitsuo Kanagae - Satoshi Mizukami - Yoshihito Tomita - Takuhiro Okabe -

Fuente: https://link.springer.com/



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