Pulmonary carcinoma with metastasis in a long-finned pilot whale Globicephala melasReportar como inadecuado




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BMC Veterinary Research

, 12:229

Oncology

Abstract

BackgroundLung cancer is the most commonly diagnosed neoplasm in humans, however this does not apply to other animal species. Living in an aquatic environment the respiratory system of cetaceans had to undergo unique adaptations in order to them to survive and cope with totally different respiratory pathogens and potentially carcinogens from those affecting humans.

Case presentationThis article discusses not only macroscopical, histopathological and immunohistochemical features of a pulmonary carcinoma with disseminated metastases in a long-finned pilot whale Globicephala melas, as well as the immunohistochemical analysis performed on various tissues of cetaceans belonging to the genus Globicephala. On the necropsy examination of the carcass, multiple pulmonary nodules and generalised thoracic lymphadenomegaly were noted. Histologically, a malignant epithelial neoplasia was identified in the lung, thoracic lymph nodes, and adrenal gland. Immunohistochemical analysis revealed a pulmonary carcinoma. Vasculogenic mimicry and epithelial-to-mesenchymal transition phenotype, as suggested by cytomorphological and immunohistochemical characteristics, were observed.

ConclusionsA diagnosis of metastatic pulmonary carcinoma was determined, which to the author’s knowledge, appears to be not previously recorded in long-finned pilot whale species. This is also the first report of vasculogenic mimicry and epithelial-to-mesenchymal transition event in a spontaneous cancer from a cetacean species.

KeywordsPulmonary carcinoma Pilot whale Cetacean Neoplasia Tumour Vasculogenic mimicry Epithelial-to-mesenchymal transition AbbreviationsACAAdenocarcinoma

CKCytokeratin

EMTEpithelial-to-mesenchymal transition

LALNLung-associated lymph node

LFPWLong-finned pilot whale

SCCSquamous cell carcinoma

VMVasculogenic mimicry

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Autor: Cristian M. Suárez-Santana - Carolina Fernández-Maldonado - Josué Díaz-Delgado - Manuel Arbelo - Alejandro Suárez-Bonne

Fuente: https://link.springer.com/







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