Effect of the plant-based hemostatic agent Ankaferd Blood Stopper® on the biocompatibility of mineral trioxide aggregateReport as inadecuate

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BMC Oral Health

, 16:111

Dental techniques; tools, materials and surgical research


BackgroundDue to the detrimental effect of blood contamination on the physico-chemical properties of mineral trioxide aggregate MTA, obtaining an effective hemostasis in the surgical crypt during apical surgery is of paramount importance. The purpose of this in vivo study was to analyze the effect of Ankaferd Blood Stopper® ABS contamination on the biocompatibility of MTA.

MethodsForty of 56 Wistar–Albino rats were divided randomly and equally into two groups MTA and MTA-ABS according to whether or not a hemostatic agent was used. The remaining 16 rats were designated as the control group. Rats in the experimental groups received freshly mixed MTA-Angelus in polyethylene tubes, which were inserted into monocortical bore holes created in their tibias. In the MTA-ABS group only, 0.5 mL of ABS solution was administered topically on the defect sites followed by implantation of MTA tubes. Inflammation, foreign-body reaction FBR, necrosis, fibrosis, and new bone formation NBF were studied 7, 30, 60, and 90 days after implantation.

ResultsOn day7, statistically significant differences were found in tissue reactions with regard to NBF and necrosis p = 0.044 and p = 0.024, respectively, the latter being observed in 40 % of the samples only in the MTA-ABS group. Slight inflammation in all groups was confined to day-7 only. Mild necrosis was present in the MTA-ABS group only on day-7. Severity of the foreign body reaction and fibrosis was limited. New bone formation increased gradually over time in all groups, reaching a maximum on day-90.

ConclusionsMTA and ABS-contaminated MTA are equally biocompatible. ABS does not impair the properties of MTA.

KeywordsAnkaferd blood stopper Biocompatibility Mineral trioxide aggregate AbbreviationsABSAnkaferd Blood Stopper

FBRForeign body reaction

MTAMineral trioxide aggregate

NBFNew bone formation

Electronic supplementary materialThe online version of this article doi:10.1186-s12903-016-0302-0 contains supplementary material, which is available to authorized users.

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Author: Muzaffer Emir Dinçol - Hakan Ozbas - Bulent Yılmaz - Handan Ersev - Selcuk Gokyay - Vakur Olgac

Source: https://link.springer.com/

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