The expression of metastasis-associated in colon cancer-1 and KAI1 in gastric adenocarcinoma and their clinical significanceReportar como inadecuado




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World Journal of Surgical Oncology

, 14:276

First Online: 28 October 2016Received: 16 March 2016Accepted: 21 October 2016

Abstract

BackgroundThe most common reason for malignant tumor treatment failure is recurrence and metastasis. Metastasis-associated in colon cancer-1 MACC1 was originally identified as a metastatic and prognostic biomarker for colon cancer and later other solid tumors. Kangai 1 KAI1, a marker of suppressor of metastasis, is also associated with metastasis and poor prognosis in many tumors. However, the prognostic value of either MACC1 or KAI1 in gastric adenocarcinoma GAC is unclear. In this study, we explored the relationship between MACC1 and KAI1 expression, as well as their respective correlation with clinicopathological features, to determine if either could be helpful for improvement of survival prognosis in GAC patients.

MethodsThe expression levels of both MACC1 and KAI1 in 325 whole-tissue sections of GAC were examined by immunohistochemistry. Clinical data was also collected.

ResultsMACC1 was significantly overexpressed in GAC tissues when compared to levels in normal gastric tissues; KAI1 was significantly down-expressed in GAC tissues when compared to levels in normal gastric tissues. Investigation of association between MACC1 and KAI1 protein levels with clinicopathological parameters of GAC indicated association between the expression of each with tumor grade, lymph node metastasis, invasive depth, and TNM stages. The overall survival time of patients with MACC1- or KAI1-positive GAC tumors was significantly shorter or longer than that of those who were negative. Importantly, multivariate analysis suggested that positive expression of either MACC1 or KAI1, as well as TNM stage, could be independent prognostic factors for overall survival in patients with GAC.

ConclusionsMACC1 and KAI1 may represent promising metastatic and prognostic biomarkers, as well as potential therapeutic targets, for GAC.

KeywordsGastric adenocarcinoma MACC1 KAI1 Metastasis Prognosis AbbreviationAJCCAmerican Joint Committee on Cancer

ECMExtracellular matrix

EMTEpithelial-mesenchymal transition

GACGastric adenocarcinoma

HGFHepatocyte growth factor

KAI1Kangai 1

LNMLymph node metastasis

MACC1Metastasis-associated in colon cancer-1

METMesenchymal-epithelial transition

OSOverall survival

TM4SFTransmembrane 4 superfamily

TNMTumor node metastasis

WHOWorld Health Organization

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Autor: Guoyu Lu - Lei Zhou - Xiaohua Zhang - Bo Zhu - Shiwu Wu - Wenqing Song - Xiaomeng Gong - Danna Wang - Yanyan Tao

Fuente: https://link.springer.com/



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