Aqueous humor polymerase chain reaction in uveitis – utility and safetyReportar como inadecuado

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BMC Ophthalmology

, 16:189

Inflammatory eye disease


BackgroundTo study the value and safety of aqueous humor polymerase chain reaction PCR analysis for Herpes simplex, varicella zoster, cytomegalovirus, Epstein-Barr virus and Toxoplasma gondii in patients with uveitis.

MethodsRecords of 45 consecutive patients with anterior and posterior uveitis who underwent AC paracentesis with PCR were reviewed. The main outcome measure was frequency of PCR positivity. Secondary outcomes were alteration of treatment, safety of paracentesis, and correlation of keratitic precipitates with PCR positivity,

ResultsThe overall PCR positivity was 48.9 % 22-45. Therapy was changed because of the PCR results in 14-45 patients 37.7 %. One patient experienced a paracentesis related complication 1-45, 2.2 % without long-term sequelae.

ConclusionAqueous PCR altered the diagnosis and treatment in over a third of our patients and was relatively safe. Aqueous PCR should be considered for uveitis of atypical clinical appearance, recurrent severe uveitis of uncertain etiology, and therapy refractory cases.

KeywordsUveitis Anterior uveitis Posterior uveitis Anterior chamber paracentesis Polymerase chain reaction PCR AbbreviationsARNAcute retinal necrosis


EBVEpstein-bar virus

FUSFuchs uveitis syndrome

HSVHerpes simplex virus

Pos-negPositive-negative PCR

PSSPosner-Schlossman syndrome


VZVVaricella zoster virus

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Autor: Argyrios Chronopoulos - Daniel Roquelaure - Georges Souteyrand - Jörg Dieter Seebach - James Scott Schutz - Gabriele Thum


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