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Current Cardiology Reports

, 18:124

Topical Collection on Stroke


Understanding the genetic risk factors for stroke is an essential step to decipher the underlying mechanisms, facilitate the identification of novel therapeutic targets, and optimize the design of prevention strategies. A very small proportion of strokes are attributable to monogenic conditions, the vast majority being multifactorial, with multiple genetic and environmental risk factors of small effect size. Genome-wide association studies and large international consortia have been instrumental in finding genetic risk factors for stroke. While initial studies identified risk loci for specific stroke subtypes, more recent studies also revealed loci associated with all stroke and all ischemic stroke. Risk loci for ischemic stroke and its subtypes have been implicated in atrial fibrillation PITX2 and ZFHX3, coronary artery disease ABO, chr9p21, HDAC9, and ALDH2, blood pressure ALDH2 and HDAC9, pericyte and smooth muscle cell development FOXF2, coagulation HABP2, carotid plaque formation MMP12, and neuro-inflammation TSPAN2. For hemorrhagic stroke, two loci APOE and PMF1 have been identified.

KeywordsStroke Ischemic stroke Hemorrhagic stroke Genome-wide association studies Multifactorial This article is part of the Topical Collection on Stroke

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Author: Ganesh Chauhan - Stéphanie Debette


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