Influence of continuous erythropoietin receptor activator CERA administration intervals on erythropoietic effect in hemodialysis patientsReportar como inadecuado




Influence of continuous erythropoietin receptor activator CERA administration intervals on erythropoietic effect in hemodialysis patients - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Renal Replacement Therapy

, 2:58

First Online: 02 November 2016Received: 05 September 2015Accepted: 19 October 2016

Abstract

BackgroundErythropoietin deficiency is the major cause of anemia in hemodialysis patients. Although continuous erythropoietin receptor activator CERA has a long half-life and once-monthly administration is recommended, the optimal interval to achieve the greatest efficacy is not known.

MethodsIn 44 hemodialysis patients, CERA was administered at an interval of once every 2 weeks Q2W and 4 weeks Q4W consecutively and reticulocyte counts and hemoglobin levels were compared prospectively. In six patients with CERA 100 μg-4 weeks, CERA intervals were further changed to 1 week Q1W.

ResultsMean reticulocyte counts were higher during Q2W than Q4W 41.5 ± 10.7 and 36.4 ± 8.8 × 10-μL, respectively, p < 0.0001, and hemoglobin levels decreased during Q4W. These results were irrespective of the CERA dose 50, 100, and 150 μg-4 weeks. In six patients with CERA 100 μg-4 weeks, although not significant, reticulocyte counts were higher during Q2W and Q1W than Q4W and hemoglobin levels were highest during Q1W p < 0.05.

ConclusionsIn our hemodialysis patients, an interval of CERA shorter than 4 weeks appeared to be more effective for the treatment of anemia.

KeywordsCERA Interval Reticulocyte Hemoglobin AbbreviationsCERAContinuous erythropoietin receptor activator

EPOErythropoietin

ESAErythropoietin-stimulating agent

Q2WOnce every 2 weeks

HbHemoglobin

RBCRed blood cell

Download fulltext PDF



Autor: Shoichiro Daimon - Hiromi Nuka - Kinya Kitada - Yasunori Suzuki - Fae Kim - Mitsuhiro Kawano

Fuente: https://link.springer.com/



DESCARGAR PDF




Documentos relacionados