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Genome Biology

, 17:239

First Online: 25 November 2016

Abstract

Nanopore DNA strand sequencing has emerged as a competitive, portable technology. Reads exceeding 150 kilobases have been achieved, as have in-field detection and analysis of clinical pathogens. We summarize key technical features of the Oxford Nanopore MinION, the dominant platform currently available. We then discuss pioneering applications executed by the genomics community.

Abbreviations5-hmC5-hydroxymethylcytosine

5-mC5-methylcytosine

CCytosine

dsDNADouble-stranded DNA

HMMHidden Markov model

ISSInternational Space Station

MAPMinION Access Program

NGSNext generation sequencing

ONTOxford Nanopore Technologies

rRNARibosomal RNA

SNVSingle nucleotide variant

An erratum to this article is available at http:-dx.doi.org-10.1186-s13059-016-1122-x.

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Autor: Miten Jain - Hugh E. Olsen - Benedict Paten - Mark Akeson

Fuente: https://link.springer.com/



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