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Protein and Cell

, Volume 7, Issue 12, pp 854–865

First Online: 14 October 2016Received: 15 September 2016Accepted: 28 September 2016


Respirasome, a huge molecular machine that carries out cellular respiration, has gained growing attention since its discovery, because respiration is the most indispensable biological process in almost all living creatures. The concept of respirasome has renewed our understanding of the respiratory chain organization, and most recently, the structure of respirasome solved by Yang’s group from Tsinghua University Gu et al. Nature 2377622:639–643, 2016 firstly presented the detailed interactions within this huge molecular machine, and provided important information for drug design and screening. However, the study of cellular respiration went through a long history. Here, we briefly showed the detoured history of respiratory chain investigation, and then described the amazing structure of respirasome.

Keywordsrespirasome structure supercomplexes organization cellular respiration respiratory complexes megacomplex  Download fulltext PDF

Autor: Runyu Guo - Jinke Gu - Meng Wu - Maojun Yang


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