Direct repair of a synthetic 5S-configured spore photoproduct by a spore photoproduct lyase.Reportar como inadecuado




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* Corresponding author 1 Department of chemistry and biochemistry 2 LCBM - UMR 5249 - Laboratoire de Chimie et Biologie des Métaux

Abstract : The spore photoproduct lyase is a Fe-S-AdoMet DNA repair enzyme, which directly repairs spore lesions, induced by UV irradiation of spores, using an unknown radical mechanism. The air sensitive radical SAM enzyme was for the first time challenged with synthetically pure substrates. It was found that the enzyme recognizes a synthetic 5S-configured spore lesion without the central phosphodiester bond. The 5R-configured lesion is in contrast to current belief not a substrate.

Keywords : DNA lesion Radical-SAM SP Lyase Spore photoproduct DNA repair





Autor: Marcus G. Friedel - Olivier Berteau - Carsten J Pieck - Mohamed Atta - Sandrine Ollagnier-De-Choudens - Marc Fontecave - Thomas C

Fuente: https://hal.archives-ouvertes.fr/



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