Vision-related quality of life and psychological status in Chinese women with Sjogren’s syndrome dry eye: a case-control studyReportar como inadecuado

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BMC Women-s Health

, 16:75

Women-s mental and emotional health


BackgroundSjogren’s syndrome dry eye SSDE mainly affects middle-aged women and can negatively affect women’s psychological and social functioning. However, little is known about the correlation between vision-related quality of life VR-QoL and psychological status for women with SSDE. We therefore examined VR-QoL and psychological status in two groups of Chinese women: an SSDE group and a non-SSDE group. We also explored the associations between VR-QoL scores, sociodemographic measures, ophthalmologic parameters, and psychological status in women with SSDE.

MethodsThe case-control study recruited 30 female outpatients with SSDE and 30 without SSDE from the Eye and Ear, Nose, and Throat ENT Hospital of Fudan University. Demographic and ophthalmologic data were collected from all participants. Ophthalmologic examinations included best-corrected visual acuity BCVA, corneal fluorescein staining CFS, tear break-up time TBUT and Schirmer test. Data collected using the National Eye Institute’s Visual Function Questionnaire NEI-VFQ and Ocular Surface Disease Index OSDI survey instruments were analyzed to identify potential differences in VR-QoL between the SSDE group and the non-SSDE group. We also used the Zung Self-Rating Anxiety and Self-Rating Depression Scales SAS and SDS to determine psychological status in both groups.

ResultsThe SSDE group scored significantly lower than the non-SSDE group on the NEI-VFQ subscales of general health, general vision, and long-distance vision activities all p < 0.05. The SSDE group achieved a significantly higher ocular symptoms score compared with the control group p = 0.0256. The SAS and SDS scores of the SSDE group were significantly higher than the non-SSDE group p = 0.0072 and 0.0162, respectively. The prevalence of anxiety and depression in the SSDE group was significantly higher than the non-SSDE group p = 0.0240 and 0.0200, respectively. Nine of twelve NEI-VFQ subscales were negatively correlated with SAS-SDS scores all p values were <0.05. The exceptions were social function, color vision and peripheral vision. The composite OSDI score and its three subscale scores for the women in the SSDE group were all positively correlated with overall SAS-SDS scores all p values were <0.05.

ConclusionsBoth VR-QoL and psychological status were significantly worse in SSDE group than in the non-SSDE group. The VR-QoL of women with SSDE had a negative correlation with their anxiety and depression levels.

KeywordsSjogren’s syndrome Dry eye Vision-related quality of life Anxiety Depression AbbreviationsBCVABest-corrected visual acuity

CFSCorneal fluorescein staining

NEI-VFQNational Eye Institute Visual Function Questionnaire

OSDIOcular Surface Disease Index

S1TSchirmer1 test without anesthesia

SASThe Zung Self-Rating Anxiety Scales

SDSThe Zung Self-Rating Depression Scales

SSSjogren’s syndrome

SSDESjogren syndrome dry eye

TBUTTear break-up time

VR-QoLVision-related quality of life

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Autor: Yuqiu Zhang - Tong Lin - Alice Jiang - Naiqing Zhao - Lan Gong


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