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Micro and Nano Systems Letters

, 3:8

First Online: 12 October 2015Received: 21 July 2015Accepted: 29 September 2015

Abstract

An ingenious combination of plasmonic nanomaterials and one of the most relevant biological systems, deoxyribonucleic acid DNA is achieved by bioconjugating gold nanorods GNRs with DNA via electrostatic interaction between positively charged GNRs and negatively charged short DNA. The obtained system is investigated as a function of DNA concentration by means of gel electrophoresis, zeta-potential, DNA melting and morphological analysis. It turns out that the obtained bioconjugated systems present both effective electric charge and aggregate size that are particularly amenable for gene therapy and nanomedicine applications. Finally, the effect of the localized photo-thermal heating and delocalized temperature variation on the DNA melting by performing both light induced bio-transparent optical heating experiments and a thermographic analysis is investigated, demonstrating that the developed system can be exploited for monitoring nanoscale temperature variation under optical illumination with very high sensitivity.

KeywordsNanomaterials Plasmonics DNA Optics Heat transfer Electronic supplementary materialThe online version of this article doi:10.1186-s40486-015-0025-z contains supplementary material, which is available to authorized users.

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Autor: Luciano De Sio - Giulio Caracciolo - Ferdinanda Annesi - Tiziana Placido - Daniela Pozzi - Roberto Comparelli - Alfredo Pa

Fuente: https://link.springer.com/







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