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Translational Neurodegeneration

, 4:19

First Online: 12 October 2015Received: 04 August 2015Accepted: 01 October 2015


Parkinson’s disease PD, the second most common age-associated neurodegenerative disorder, is characterized by the loss of dopaminergic DA neurons and the presence of α-synuclein-containing aggregates in the substantia nigra pars compacta SNpc. Chronic neuroinflammation is one of the hallmarks of PD pathophysiology. Post-mortem analyses of human PD patients and experimental animal studies indicate that activation of glial cells and increases in pro-inflammatory factor levels are common features of the PD brain. Chronic release of pro-inflammatory cytokines by activated astrocytes and microglia leads to the exacerbation of DA neuron degeneration in the SNpc. Besides, peripheral immune system is also implicated in the pathogenesis of PD. Infiltration and accumulation of immune cells from the periphery are detected in and around the affected brain regions of PD patients. Moreover, inflammatory processes have been suggested as promising interventional targets for PD and even other neurodegenerative diseases. A better understanding of the role of inflammation in PD will provide new insights into the pathological processes and help to establish effective therapeutic strategies. In this review, we will summarize recent progresses in the neuroimmune aspects of PD and highlight the potential therapeutic interventions targeting neuroinflammation.

KeywordsParkinson’s disease Neurodegeneration Glial cells Neuroinflammation  Download fulltext PDF

Autor: Qinqin Wang - Yingjun Liu - Jiawei Zhou


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