Ebola virus disease complicated with viral interstitial pneumonia: a case reportReport as inadecuate

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BMC Infectious Diseases

, 15:432

Viral diseases


BackgroundIn the current Ebola epidemic in Western Africa, many healthcare workers have become infected. Some of these have been medically evacuated to hospitals in Europe and the USA. These clinical experiences provide unique insights into the course of Ebola virus disease under optimized condition within high level isolation units.

Case presentationA 50-year-old Caucasian male physician contracted Ebola virus diseases in Sierra Leone and was medically evacuated to Italy. Few days after the admission the course of the illness was characterized by severe gastro-intestinal symptoms followed by respiratory failure, accompanied by pulmonary infiltration and high Ebola viral load in the bronchial aspirate and Plasmodium vivax co-infection. The patient received experimental antiviral therapy with favipiravir, convalescent plasma and ZMAb. Ebola viral load started to steadily decrease in the blood after ZMAb administration and became undetectable by day 19 after admission, while it persisted longer in urine samples. No temporal association was observed between viral load decay in plasma and administration of favipiravir. The patient completely recovered and was discharged 39 days after admission.

ConclusionsThis is the first case of Ebola-related interstitial pneumonia documented by molecular testing of lung fluid specimens. This reports underlines the pivotal role of fluid replacement and advanced life support with mechanical ventilation in the management of patients with Ebola virus diseases respiratory failure. Beside our finding indicates a close temporal association between administration of cZMAb and Ebola virus clearance from blood.

KeywordsHemorrhagic fever Ebola Pneumonia, viral Malaria, vivax Immunization, passive Antibodies, monoclonal Favipiravir Fluid therapy Life support care Hospitals, isolation AbbreviationsEBOVEbola virus Makona variant

EVDEbola virus disease

PCRPolymerase chain reaction

RNARibonucleic acid

P. vivaxPlasmodium vivax

ALTAlanine amino transferase

ICUIntensive care unit

CVCCentral venous catheter



tidTer in die thrice time a day

bidBis in die twice a day

qidQuater in die four times a day


LogDecimal logarithm

Electronic supplementary materialThe online version of this article doi:10.1186-s12879-015-1169-4 contains supplementary material, which is available to authorized users.

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Author: Nicola Petrosillo - Emanuele Nicastri - Simone Lanini - Maria Rosaria Capobianchi - Antonino Di Caro - Mario Antonini - Vin

Source: https://link.springer.com/


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