Intake of high fructose corn syrup sweetened soft drinks is associated with prevalent chronic bronchitis in U.S. Adults, ages 20–55 yReportar como inadecuado




Intake of high fructose corn syrup sweetened soft drinks is associated with prevalent chronic bronchitis in U.S. Adults, ages 20–55 y - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Nutrition Journal

, 14:107

First Online: 16 October 2015Received: 13 April 2015Accepted: 07 October 2015

Abstract

BackgroundHigh fructose corn syrup HFCS sweetened soft drink intake has been linked with asthma in US high-schoolers. Intake of beverages with excess free fructose EFF, including apple juice, and HFCS sweetened fruit drinks and soft drinks, has been associated with asthma in children. One hypothesis for this association is that underlying fructose malabsorption and fructose reactivity in the GI may contribute to in situ formation of enFruAGEs. EnFruAGEs may be an overlooked source of advanced glycation end-products AGE that contribute to lung disease. AGE- RAGEs are elevated in COPD lungs. EFF intake has increased in recent decades, and intakes may exceed dosages associated with adult fructose malabsorption in subsets of the population. Intestinal dysfunction has been shown to be elevated in COPD patients. The objective of this study was to investigate the association between HFCS sweetened soft drink intake and chronic bronchitis CB, a common manifestation of COPD, in adults.

MethodsDesign: In this cross sectional analysis, the outcome variable was self-reported existing chronic bronchitis or history of CB. Exposure variable was non-diet soda. Rao Scott Ҳ was used for prevalence differences and logistic regression for associations, adjusted for age, sex, race-ethnicity, BMI, smoking, exposure to in-home smoking, pre-diabetes, diabetes, SES, total energy and total fruits and beverages consumption.

SettingData are from the National Health and Nutrition Examination Survey 2003–2006.

Subjects2801 adults aged 20–55 y.

ResultsThere was a statistically significant correlation between intake of non-diet soft drinks and greater prevalence and odds of chronic bronchitis p < 0.05. Independent of all covariates, intake of non-diet soda ≥5 times a week vs. non-low non-diet soda was associated with nearly twice the likelihood of having chronic bronchitis OR = 1.80; p = 0.047; 95 % CI 1.01–3.20.

ConclusionsHFCS sweetened soft drink intake is correlated with chronic bronchitis in US adults aged 20–55 y, after adjusting for covariates, including smoking. Results support the hypothesis that underlying fructose malabsorption and fructose reactivity in the GI may contribute to chronic bronchitis, perhaps through in situ formation of enFruAGEs, which may contribute to lung disease. Longitudinal and biochemical research is needed to confirm and clarify the mechanisms involved.

KeywordsChronic bronchitis COPD Advanced glycation end-products Fructose Fructose malabsorption Fructositis HFCS Excess free fructose EnFruAGE EFF High fructose corn syrup AbbreviationsAGEsAdvanced glycation end-products

ALAAmerican Lung Association

BMIBody mass index

CBChronic bronchitis

COPDChronic obstructive pulmonary disease

EFFExcess free fructose

enFruAGEExtracellular, newly identified, fructose associated advanced glycation end-product

FFQFood frequency questionnaire

FMFructose malabsorption

GIGastro intestinal

HFCSHigh fructose corn syrup

NDBUS National nutrient database for standard reference

NHANESNational Health and Nutrition Examination Survey

RAGEReceptor of advanced glycation end-products

SESSocioeconomic status

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Autor: Luanne Robalo DeChristopher - Jaime Uribarri - Katherine L. Tucker

Fuente: https://link.springer.com/







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