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World Journal of Surgical Oncology

, 13:303

First Online: 16 October 2015Received: 13 March 2015Accepted: 05 October 2015

Abstract

BackgroundThymomas represent an uncommon and heterogeneous group of intrathoracic malignancies which require different treatments corresponding to their individual tumor stage. The objective of this study was to review the efficacy of our applied stage-based treatment for thymoma in due consideration of thymectomy.

MethodsThis is a single-center, institutional review board-approved retrospective study of 50 consecutive patients with thymoma treated at our division within 10 years.

ResultsThere were 29 women 58 % and 21 men 42 %, mean age 58.3 years. Twenty nine 58 % had clinical symptoms and 14 28 % had myasthenia gravis. Forty-five patients 90 % underwent thymectomy and complete resection was done in 42 cases 93.3 %. Histologic results were 6 subtype A, 5 AB, 8 B1, 12 B2, 12 B3, and 7 C. The Masaoka staging system revealed 20 stage I, 18 stage II, 6 stage III, and 6 stage IV. Two patients had neoadjuvant therapy and 25 received postoperative treatment. Five 11.1 % had tumor recurrence, treated with re-resection. The 5-year disease-free survival was 91.5 %. Two patients died of tumor progression and three died of other causes 10 %. The 5-year overall survival was 82.3 % and the median survival time was 92.1 months. The 5-year survival rate after thymectomy was 87.2 % and the median survival was 92.1 months.

ConclusionsComplete resection still remains the mainstay in the treatment of non-metastatic thymoma and should be performed whenever feasible. Close multidisciplinary teamwork is mandatory to optimize the neurologic outcome and to prolong postoperative survival.

KeywordsThymoma Surgery Thymectomy Myasthenia gravis Survival  Download fulltext PDF



Autor: Joerg Lindenmann - Nicole Fink-Neuboeck - Martin Pichler - Udo Anegg - Alfred Maier - Josef Smolle - Freyja Maria Smolle-J

Fuente: https://link.springer.com/







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