Concentration dependent toxicokinetics of copper in the red flour beetle Tribolium castaneum Coleoptera: TenebrionidaeReportar como inadecuado




Concentration dependent toxicokinetics of copper in the red flour beetle Tribolium castaneum Coleoptera: Tenebrionidae - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Ecotoxicology

, Volume 24, Issue 9, pp 1823–1830

First Online: 14 July 2015Accepted: 08 July 2015

Abstract

To predict internal metal concentrations in animals under specific environmental exposures, the relationship between the exposure concentrations and values of toxicokinetic parameters must be known. At high exposure levels, the availability of carriers transporting metal ions through cellular membranes may become limited, thereby decreasing the assimilation rates kA. Furthermore, increased metal concentrations in food may result in greater damage to the gut and reduce the assimilation efficiency and-or increase the elimination rate kE. Therefore, kA should decrease and kE should increase with increasing metal concentrations. In fact, our study on Tribolium castaneum exposed to Cu at 500, 1000, 2000 and 4000 mg kg of dry flour showed that with increasing Cu concentrations, kA decreased from 0.0042 day at 500 mg kg to 0.0026 day at 4000 mg kg in females and from 0.0029 to 0.001 day in males and kE increased from 0.027 to 0.064 day and from 0.018 to 0.04 day in females and males, respectively. Significant differences in kA between the sexes were observed at 2000 and 4000 mg kg, whereas significant differences between treatments were found for kA in males. Copper was efficiently regulated by T. castaneum: an eightfold increase in exposure concentrations resulted in only a ca. twofold increase in the internal concentration. No Cu effect on the respiratory metabolism of T. castaneum was found.

KeywordsToxicokinetic One-compartment model Assimilation Elimination Respiration rate  Download fulltext PDF



Autor: Agnieszka J. Bednarska - Katarzyna Stępień

Fuente: https://link.springer.com/



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