An increase in IL-1β concentrations in embryo culture-conditioned media obtained by in vitro fertilization on day 3 is related to successful implantationReportar como inadecuado




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Journal of Assisted Reproduction and Genetics

, Volume 32, Issue 11, pp 1623–1627

First Online: 26 September 2015Received: 30 June 2015Accepted: 07 September 2015

Abstract

PurposeThis study aimed to evaluate interleukin IL-1β concentrations in maternal serum and in embryo-cultured conditioned media and to correlate these findings with success of implantation.

MethodsA total of 70 infertile women who underwent in vitro fertilization treatment were studied. IL-1β concentrations were quantified in maternal serum and in embryo culture-conditioned media on days 1 and 3. The findings were compared between those who achieved pregnancy and those who did not.

ResultsNo significant differences were found in IL-1β serum concentrations between the groups. IL-1β was not detected in day 1 culture-conditioned medium. On day 3, IL-1β was quantified in 27 patients, and IL-1β concentrations were significantly higher in women who achieved pregnancy than in those who did not p < 0.001.

ConclusionsHigh IL-1β concentrations in day 3 culture-conditioned medium in patients who achieve pregnancy after in vitro fertilization treatment indicate a possible role of embryonic IL-1β in the implantation process.

KeywordsEmbryo Implantation Interleukin-1β In vitro fertilization Capsule High IL-1β concentrations in culture-conditioned medium after in vitro fertilization treatment suggest a role of embryonic IL-1β in the success of implantation.

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Autor: Karina Sequeira - Aurora Espejel-Núñez - Eva Vega-Hernández - Anayansi Molina-Hernández - Patricia Grether-González

Fuente: https://link.springer.com/







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