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Stem Cell Research and Therapy

, 6:212

Extracellular vesicles and regenerative medicine


Extracellular vesicles EVs play important roles in intercellular communications via their content molecules, and mimic, at least in part, the roles that are played by their originating cells. Consistent with this notion, an increasing number of reports have suggested that EVs derived from mesenchymal stem cells MSCs, which are therapeutically beneficial to a wide range of diseases, can serve as drugs to treat multiple diseases. EVs contain a variety of molecules, including proteins, microRNAs, and mRNAs, and are associated with biological processes in a content molecule-dependent manner. In this article, we review the latest reports regarding the therapeutic potential of MSC-EVs by focusing on the underlying molecular mechanisms of their effects. Specifically, we feature the effects of MSC-EVs in terms of their content molecules and of the tissue recovery processes endowed by these molecules.

AbbreviationsADSCAdipose tissue-derived mesenchymal stem cell

ALIAcute lung injury

ATIIAlveolar epithelial type II

Aβamyloid beta

BMBone marrow

BMPBone morphogenetic protein

EVExtracellular vesicle

GVHDGraft-versus-host disease

KGFKeratinocyte growth factor

MAPKMitogen-activated protein kinase

MIRMyocardial ischemia-reperfusion injury


MSCMesenchymal stem cell

MSC-EVExtracellular vesicle derived from mesenchymal stem cell

PPARPeroxisome proliferator-activated receptor

PTENPhosphatase and tensin homolog

RNAiRNA interference

RNA-seqRNA sequencing

TGFβTransforming growth factor beta

Th1T-helper type 1

TregRegulatory T cell

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Author: Takeshi Katsuda - Takahiro Ochiya


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