Prognostic impact of immunohistochemical expression of CK7 and CK20 in curatively resected ampulla of Vater cancerReportar como inadecuado




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BMC Gastroenterology

, 15:165

First Online: 24 November 2015Received: 16 June 2015Accepted: 18 November 2015

Abstract

BackgroundIn the consideration of ampullary adenocarcinoma, T stage, lymph node metastases, perineural invasion, tumor differentiation, pancraticobiliary type, and lymph node ratio are considered prognostic factors. The objectives of this study were to investigate surgical outcomes and the clinicopathological predictors affecting survival and recurrence, and to examine the prognostic roles of histopathological subtype and immunohistochemical markers.

MethodsFrom April 2006 to September 2012, 37 patients who underwent curative resection of ampullar of Vater adenocarcinoma were enrolled in this study. A retrospective review was performed based on medical records. Immunohistochemical expression, histopathological type and clinicopathologic factors were analyzed.

ResultsThe 5-year overall survival rates and disease-free survival rates after surgery were 77.4 and 75.7 %, respectively. Multivariate Cox regression analysis showed that advanced T stage p = 0.019 and positive expression of Cytokeratin 7 CK7 with negative expression of Cytokeratin 20 CK20 p = 0.046 were identified as significant independent factors related to survival, and poor differentiation p = 0.031 significantly influenced disease-free survival in multivariate analysis.

ConclusionsAdvanced T stage is a significant prognostic factor affecting survival in ampullary adenocarcinoma. Also, positive expression of CK7 with negative expression of CK20 is an independent factor related to overall survival.

KeywordsAmpulla of Vater adenocarcinoma Prognostic factor Immunohistochemical expression CK7 CK20 AbbreviationsAoVAmpulla of Vater

CK7Cytokeratin 7

CK20Cytokeratin 20

CA 19–9Carbohydrate antigen 19–9

CEACarcinoembryonic antigen

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Autor: Sung Pil Yun - Hyung Il Seo

Fuente: https://link.springer.com/



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