Associations between the erythropoiesis-stimulating agent resistance index and the geriatric nutritional risk index of maintenance hemodialysis patients and increased mortalityReportar como inadecuado




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Renal Replacement Therapy

, 1:7

First Online: 24 November 2015Received: 03 July 2015Accepted: 31 August 2015

Abstract

BackgroundThere may be an association between the responsiveness to erythropoiesis-stimulating agent ESA and the nutritional status on mortality of maintenance hemodialysis MHD patients. Therefore, we assessed the associations of geriatric nutritional risk index GNRI and ESA resistance index ERI in mortality in MHD patients.

MethodsA total of 298 MHD patients were enrolled. Unadjusted and adjusted Cox regression analyses for all-cause mortality were performed. Odds ratios were estimated using a logistic regression model for the association between the GNRI and ERI and mortality, adjusting for potential confounders.

ResultsDuring the follow-up period of 34.6 ± 6.1 months, 51 died with 31 cardiovascular deaths. Receiver operating curve analyses indicated the cutoff values of GNRI and ERI for mortality were 94.9 and 13.5, respectively. When subjects were stratified by ERI and GNRI values into four groups, those who had low GNRI and high ERI were associated with the highest risk of mortality among the four groups log-rank p < 0.001.

ConclusionsHigh ERI and low GNRI were associated with an increased risk of all-cause mortality.

KeywordsGeriatric nutritional risk index Erythropoiesis-stimulating agent Hyporesponsiveness Hemodialysis Mortality  Download fulltext PDF



Autor: Masayuki Okazaki - Mizuki Komatsu - Shunji Shiohira - Hiroshi Kataoka - Ken Tsuchiya - Hiroshi Kawaguchi - Kosaku Nitta

Fuente: https://link.springer.com/



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