Comparison of tripterygium wilfordii multiglycosides and tacrolimus in the treatment of idiopathic membranous nephropathy: a prospective cohort studyReportar como inadecuado




Comparison of tripterygium wilfordii multiglycosides and tacrolimus in the treatment of idiopathic membranous nephropathy: a prospective cohort study - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Nephrology

, 16:200

First Online: 04 December 2015Received: 14 June 2015Accepted: 28 November 2015

Abstract

BackgroundIdiopathic membranous nephropathy IMN is a major cause of nephrotic syndrome among adults. Considering the natural course of IMN, when to treat and with which immunosuppressive treatment need to be carefully considered in such patients. A combination of tripterygium wilfordii multiglycosides TWG and prednisone may be an effective option for treating patients with IMN.

MethodsIn this prospective cohort study, we enrolled patients with biopsy-proven IMN at our kidney centre. One cohort received TWG combined with prednisone, whereas another cohort received tacrolimus TAC combined with prednisone, for 36 weeks. The primary outcome was the remission rate, whereas the secondary outcomes included the time to remission, relapse rate, changes in serum albumin levels and daily urinary protein levels, estimated glomerular filtration rate, and adverse events.

ResultsA total of 53 patients with IMN met the criteria for enrolment, and all patients completed the therapy. At the end of the 36-week therapy, remission either partial remission PR or complete remission CR was observed in 20 patients 86.9 % receiving TWG and in 27 patients 90.0 % receiving TAC p > 0.05, whereas CR was noted in 12 patients 52.2 % receiving TWG and 14 patients 46.7 % receiving TAC p > 0.05. The probability of remission was similar for both the TWG and TAC groups p > 0.05, by log-bank test. The mean time for achieving remission was 11.8 ± 12.5 weeks in the TWG group and 8.5 ± 9.1 weeks in the TAC group p > 0.05.

ConclusionsThe combination of TWG and predisone is an effective and safe therapy for IMN.

KeywordsIdiopathic membranous nephropathy Tripterygium wilfordii Hook F Tripterygium wilfordii multiglycosides Tacrolimus AbbreviationsTACtacrolimus

TWGTripterygium wilfordii multiglycosides

KDIGOKidney Disease, Improving Global Outcomes

BMIBody Mass Index

Scrserum creatinine

BUNblood urea nitrogen

UAUric acid

eGFRestimated glomerular filtration rate, calculated using 6-variable MDRD Modification of Dietin Renal Disease Study equation

Hbhaemoglobin

TGTriglyceride

TchTotal cholesterol

LDLLow density lipoprotein

HDLHigh density lipoprotein

Shanshan Liu and Xiayu Li contributed equally to this work.

Download fulltext PDF



Autor: Shanshan Liu - Xiayu Li - Heng Li - Qian Liang - Jun Chen - Jianghua Chen

Fuente: https://link.springer.com/







Documentos relacionados