Ischemic heart disease among subjects with and without chronic obstructive pulmonary disease – ECG-findings in a population-based cohort studyReportar como inadecuado

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BMC Pulmonary Medicine

, 15:156

Epidemiology and public health


BackgroundCardiovascular comorbidity in COPD is common and contributes to increased mortality. A few population-based studies indicate that ischemic electrocardiogram ECG-changes are more prevalent in COPD, while others do not. The aim of the present study was to estimate the presence of ischemic heart disease IHD in a population-based COPD-cohort in comparison with subjects without COPD.

MethodsAll subjects with obstructive lung function COPD, n = 993 were identified together with age- and sex-matched controls non-COPD, n = 993 from population-based cohorts examined in 2002–04. In 2005, data from structured interview, spirometry and ECG were collected from 1625 subjects. COPD was classified into GOLD 1–4 after post-bronchodilator spirometry. Ischemic ECG-changes, based on Minnesota-coding, were classified according to the Whitehall criteria into probable and possible IHD.

ResultsSelf-reported IHD was equally common in COPD and non-COPD, and so were probable and possible ischemic ECG-changes according to Whitehall. After excluding subjects with restrictive spirometric pattern from the non-COPD-group, similar comparison with regard to presence of IHD performed between those with COPD and those with normal lung-function did neither show any differences. There was a significant association between self-reported IHD p = 0.007 as well as probable ischemic ECG-changes p = 0.042, and increasing GOLD stage. In COPD there was a significant association between level of FEV1 percent of predicted and self-reported as well as probable ischemic ECG-changes, and this association persisted for self-reported IHD also after adjustment for sex and age.

ConclusionIn this population-based study, self-reported IHD and probable ischemic ECG-changes were associated with COPD disease severity assessed by spirometry.

KeywordsComorbidity Epidemiology Coronary disease Respiratory diseases AbbreviationsBMIbody mass index

CABGcoronary artery bypass graft

COPDchronic obstructive pulmonary disease

CVDcardiovascular disease


FEV1forced expiratory volume during one second

FVCforced vital capacity

GOLDglobal initiative for chronic obstructive lung disease

IHDischemic heart disease

LBBBleft bundle branch block

MCMinnesota code

NLFnormal lung function

PCIpercutaneous coronary intervention

SVCslow vital capacity

VCvital capacity

Electronic supplementary materialThe online version of this article doi:10.1186-s12890-015-0149-1 contains supplementary material, which is available to authorized users.

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Autor: Ulf Nilsson - Bengt Johansson - Berne Eriksson - Anders Blomberg - Bo Lundbäck - Anne Lindberg


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