Incidence of new-onset wheeze: a prospective study in a large middle-aged general populationReportar como inadecuado

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BMC Pulmonary Medicine

, 15:163

Epidemiology of musculoskeletal disorders


BackgroundWheeze is a very common respiratory symptom, which is associated with several factors and diseases. Studies on incidence of new-onset wheeze in general adult populations are rare. The present prospective study aimed to investigate the incidence rate of new-onset wheeze, and predictors for wheeze, in a general, middle-aged population.

MethodsIndividuals, born 1943–1973, who had participated in a previous Swedish study in 1993 n = 15,813, were mailed a new respiratory questionnaire in 2003. The questionnaire, which included items about respiratory symptoms, atopy, and smoking was answered by 11,463 72 %. Incidence rates of new-onset wheeze were calculated. Cox regression analyses were performed with incident wheeze as an event and person-years under observation as dependent variable.

ResultsAmong those free of wheeze at baseline n = 8885, there were 378 new cases of wheeze during the study period 1993–2003. The incidence rate was 4.3-1000 person-years. The adjusted risk was increased in relation to smoking HR 2.1;95 % CI 1.7–2.7, ex-smoking HR 1.4;95 % CI 1.1–1.9, young age HR 1.7;95 % CI 1.3–2.2, chronic bronchitis HR 2.3;95 % CI 0.96–5.7, and rhinitis HR 1.8;95 % CI 1.4–2.2 at baseline, and body mass index ≥30 HR 1.9;95 % CI 1.5–2.6 at follow-up.

ConclusionsThis is a unique study that presents an incidence rate for new-onset wheeze in a middle-aged, general population sample previously free of adult wheeze. The results indicate that new-onset wheeze is quite common in this age group. Health care staff should bear this in mind since new-onset wheeze could be one of the earliest symptoms of severe respiratory disease. Special attention should be paid to patients with a smoking history, chronic bronchitis, rhinitis or obesity.

KeywordsWheeze Incidence Prospective Predictors Smoking Chronic bronchitis Rhinitis Obesity  Download fulltext PDF

Autor: Mathias Holm - Kjell Torén - Eva Andersson


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