Polyhydroxybutyrate PHB-based triblock copolymers: synthesis of hydrophobic PHB-polybenzyl beta-malolactonate and amphiphilic PHB-polymalic acid analogues by ring-opening polymerizationReportar como inadecuado




Polyhydroxybutyrate PHB-based triblock copolymers: synthesis of hydrophobic PHB-polybenzyl beta-malolactonate and amphiphilic PHB-polymalic acid analogues by ring-opening polymerization - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1 ISCR - Institut des Sciences Chimiques de Rennes

Abstract : Polyhydroxyalkanoates PHAs are biocompatible and biodegradable polyesters widely used for biomedical applications. Amphiphilic triblock copolymers with a PHB hydrophobic segment recently demonstrated attractive advantages such as high colloidal stability and low critical micellar concentration CMC values for the elaboration of drug delivery systems. Our approach aims at associating PHB with a fully biodegradable hydrophilic block to access new self-assembled systems with unique potential. Well-defined alpha,omega-dihydroxy telechelic PHA-based hydrophobic triblock copolymers with tunable segments length were synthesized by the controlled ring-opening polymerization ROP of benzyl beta-malolactonate, using polyhydroxybutyrate PHB diol-NdOTf3 as the catalytic system. Remarkably, the reaction proceeds with the selective oxygen-acyl bond cleavage of the beta-lactone. The corresponding amphiphilic copolymers were then obtained by hydrogenolysis. These copolymers are the only examples of fully biodegradable PHA-PHB-PHA triblock copolymers. The hydrophilic weight fraction of the copolymers was tuned from 7 to 83% upon modulating the monomer loading thus affording the ability to next access different self-assembling architectures.

Keywords : butyrolactone controlled rop malic acid block polyethylene benzyl beta-malolactone murine xenograft model drug-delivery diblock copolymers polymers





Autor: Ghislaine Barouti - Sophie M. Guillaume -

Fuente: https://hal.archives-ouvertes.fr/



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