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Virology Journal

, 12:223

Positive-strand RNA viruses

Abstract

BackgroundDengue is the most prevalent arboviral disease in tropical and sub-tropical areas of the world. The incidence of infection is estimated to be 390 million cases and 25,000 deaths per year. Despite these numbers, neither a specific treatment nor a preventive vaccine is available to protect people living in areas of high risk.

ResultsWith the aim of seeking a treatment that can mitigate dengue infection, we demonstrated that the quinic acid derivatives known as compound 2 and compound 10 were effective against all four dengue virus serotypes and safe for use in a human hepatoma cell line Huh7.5. Both compounds were non-virucidal to dengue virus particles and did not interfere with early steps of the dengue virus life cycle, including binding and internalization. Experiments using a replicon system demonstrated that compounds 2 and 10 impaired dengue virus replication in Huh7.5 cells. Additionally, the anti-dengue virus effects of the quinic acid derivatives were preserved in human peripheral blood mononuclear cells.

ConclusionsTaken together, these data suggest that quinic acid derivatives represent a novel chemical class of active compounds that could be used to combat dengue virus infection.

KeywordsDengue Replication Antivirals Quinic acid Paula Rodrigues Zanello and Andrea Cristine Koishi contributed equally to this work.

Electronic supplementary materialThe online version of this article doi:10.1186-s12985-015-0443-9 contains supplementary material, which is available to authorized users.

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Autor: Paula Rodrigues Zanello - Andrea Cristine Koishi - Celso de Oliveira Rezende Júnior - Larissa Albuquerque Oliveira - Adr

Fuente: https://link.springer.com/



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