Preferential epithelial expression of type-1 cannabinoid receptor CB1R in the developing canine embryoReport as inadecuate

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, 4:804

Biomedical and LifeSciences


The use of cannabinoid receptor agonists is gaining a strong interest both in human and veterinary medicine. The potential use of cannabimimetic compounds in companion animals was reviewed in 2007 for their role in tissue inflammation and pain. A better knowledge of type-1 cannabinoid receptor CB1R expression on the target population may help in risk management in order to prevent unwanted side effects. We used 30-days old canine embryos to describe the distribution of CB1R by means of immunohistochemistry with a commercially available antibody.CB1R immunoreactivity was mainly epithelial and included most structures of central and peripheral nervous system, inner ear, olfactory epithelium and related structures, eye and thyroid. Further investigative research on the role of the endocannabinoid system in the developmental biology field is needed, however, we show that in the canine species we must consider pregnancy as risk condition for developmental abnormalities that may arise upon the use of CB1R receptor agonists.

KeywordsCannabinoid receptor 1 Embryo Dog Immunohistochemistry Abbreviations2-AG2-arachidonoylglycerol


CB1Rtype-1 cannabinoid receptor

CB2Rtype-2 cannabinoid receptor



mesmesothelial layer of the cornea

mrmedullary raphe


optoptic nerve


pmoprimordia of medulla oblongata


thydeveloping thyroid




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Author: Andrea Pirone - Carla Lenzi - Alessandra Coli - Elisabetta Giannessi - Maria Rita Stornelli - Vincenzo Miragliotta


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