The prophylactic effects of a traditional Japanese medicine, goshajinkigan, on paclitaxel-induced peripheral neuropathy and its mechanism of actionReportar como inadecuado




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Molecular Pain

, 10:61

First Online: 21 September 2014Received: 10 July 2014Accepted: 18 September 2014

Abstract

BackgroundThis study aimed to evaluate the prophylactic effect of goshajinkigan GJG on paclitaxel PTX-induced neuropathy and to elucidate the mechanism of action.

ResultsThere was a time-dependent irreversible decrease in pain threshold in PTX group. In PTX-GJG group, pain threshold showed changes in the same level as control. Electron microscope showed that although the ganglion cells of control and PTX-GJG groups were normal, degeneration of the nucleus and swelling of the mitochondria were observed in PTX group. Expression of transient receptor potential vanilloid 4 TRPV4 gene in PTX group significantly increased compared with that in control and PTX-GJG groups. In TRPV4 knock-out mice, no PTX-induced hyperalgesia was observed, and there was no significant difference in pain threshold between the 3 groups.

ConclusionsThese results showed that PTX induced hyperalgesia by enhancing TRPV4 expression, and suggested that GJG might alleviate hyperalgesia by preventing degeneration of the ganglion cells and suppressing TRPV4 expression.

KeywordsPaclitaxel Goshajinkigan Peripheral neuropathy Degeneration of the ganglion cells TRPV4 Electronic supplementary materialThe online version of this article doi:10.1186-1744-8069-10-61 contains supplementary material, which is available to authorized users.

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Autor: Yukiko Matsumura - Yoshihito Yokoyama - Hachidai Hirakawa - Tatsuhiko Shigeto - Masayuki Futagami - Hideki Mizunuma

Fuente: https://link.springer.com/







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